Dissolving Microneedles for Rapid and Painless Local Anesthesia
نویسندگان
چکیده
منابع مشابه
Rapid local anesthesia in humans using minimally invasive microneedles.
OBJECTIVE This study tested the hypothesis that minimally invasive microneedles cause less pain during injection of lidocaine, but induce local anesthesia in humans with the same rapid onset and efficacy as intradermal lidocaine injection using hypodermic needles. METHODS This study was a randomized, single-blinded, within participants, controlled design. Hollow, 500-μm long microneedles were...
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Biomolecules, including proteins, peptides, and vaccines, make up a large and potent portion of all new drugs and hold great promise for the future of therapeutics. Although oral delivery of these biotherapeutics would be desirable, there is low bioavailability of biomolecules administered by this route due to enzymatic degradation and poor absorption in the GI tract, as well as first-pass meta...
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It is unfortunate that the methods used to control dental operative pain may themselves produce distress. It should be the aim of all caring practitioner to reduce injection sensation to minimum so as to alleviate the apprehension and fear from the patient’s mind. The fear of needle prick is a bigger reason of concern and the major cause of avoidance of dental treatment despite the detrimental ...
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Dissolving microneedle patches offer promise as a simple, minimally invasive method of drug and vaccine delivery to the skin that avoids the need for hypodermic needles. However, it can be difficult to control the amount and localization of drug within microneedles. In this study, we developed novel microneedle designs to improve control of drug encapsulation and delivery using dissolving micro...
متن کاملComputer-controlled local anesthetic delivery for painless anesthesia: a literature review
Local anesthesia is administered to reduce pain during dental treatments, but may itself cause pain and contribute to increased dental fear. Computer-controlled local anesthetic delivery (CCLAD) is one the method to reduce patient pain during local anesthesia; it is a device that slowly administers anesthetics by using a computerized device to control the injection speed. This literature review...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2020
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics12040366